![]() However, orange or apple juice can cause an interaction with fexofenadine (Allegra) and aliskerin (Tekturna). For most medications, orange juice, apple juice, or grape juice can be consumed instead of grapefruit juice without any concern for an interaction. Other kinds of fruit juice besides grapefruit juice may rarely interfere with medications. What other types of juice interact with drugs? In some cases, you may be able to drink smaller quantities of grapefruit juice, so you should follow the directions on the patient information leaflet for each individual drug or ask your healthcare provider. So, even if you take a medicine that is given only once per day, grapefruit and grapefruit juice should still be avoided for the entire treatment period. The effects of grapefruit juice on certain medications can last for over 24 hours. Taking medications at a different time from when grapefruit juice is consumed will not prevent the interaction. Can I take my medicine at a different time from grapefruit juice to prevent the interaction? If you have been warned about a possible drug interaction with grapefruit, ask your healthcare provider to describe the possible side effect and learn how to recognize it. Other reactions may occur - it depends on the drug and the levels of the drug in the blood. Side effects can range from abnormal heart rhythms, stomach bleeding, muscle pain, muscle breakdown, kidney damage, low blood pressure, difficulty breathing, sedation, and dizziness. Side effects can vary based on the interacting drug and possible side effects. ![]() If you drink grapefruit juice, always have your pharmacist run a drug interaction check with your medications to rule out an interaction before you combine them. ![]() Not all drugs in any one drug class usually have a grapefruit interaction, so usually your doctor can select an alternative medication. One whole fruit or 200 milliliters of grapefruit juice (a bit less than one cup) can block the CYP3A4 enzymes and lead to toxic blood levels of the drug.Blood levels of the drug may rise, resulting in a risk for new or worsened side effects.When grapefruit juice is consumed, the enzyme’s ability to break down the drug for elimination is decreased. Grapefruit contains compounds known as furanocoumarins that block the CYP3A4 enzymes.Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins.Grapefruit or grapefruit juice can alter enzymes in the body and affect how drugs are changed in the body before they are eliminated. Why does grapefruit interact with drugs?ĭrugs or toxins are usually broken down (metabolized) so that they can be eliminated from the body. Some immunosuppressants have been reported to cause kidney damage, and certain pain medications when mixed with grapefruit juice may be linked with depressed breathing. Check with your pharmacist or doctor to confirm any interactions you may find.Įxamples of common medications that interact with grapefruit juice include certain statin cholesterol drugs such as atorvastatin (Lipitor), lovastatin, simvastatin (Zocor), felodipine (Plendil) and other calcium channel blockers, clarithromycin (Biaxin), and loratadine (Claritin). New drugs are approved frequently, so it is wise to research your drug interactions with grapefruit juice drug with the Drugs Interaction Checker.This can lead to enhanced side effects or lower drug effectiveness. Grapefruit juice affects how drugs are changed (metabolized) in the body for eventual elimination and can alter the amount of drug in your blood.Interactions with grapefruit can occur with common and important medications - such as those that lower cholesterol, treat high blood pressure, or even those that fight cancer.Grapefruit juice interactions can even occur with over-the-counter (OTC) drugs. Maybe you've receive a medication prescription container with an affixed warning label that recommends you avoid grapefruit or grapefruit juice while taking the medication. While grapefruit is a nutritious fruit, many patients are concerned about the potential for drug interactions with grapefruit juice. Which drugs interact? | Why does grapefruit juice interact with drugs? | Possible side effects | Timing | Which other juices interact? | Common drugs that interact with grapefruit juice | Other resources Which drugs interact with grapefruit juice? Keep in mind that each category contains several other medications that aren't affected by grapefruit.Medically reviewed by Leigh Ann Anderson, PharmD. Grapefruit and grapefruit juice can boost blood levels of various prescription medications. Some of the most common drugs affected by grapefruit are listed below. The potency of some cardiovascular and other drugs is affected by grapefruit, pomelo, and other juices.
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